Portada del sitio > Estudios Científicos > Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular (...)
SCIENTIFIC REPORTS | 2 : 312 | DOI: 10.1038/srep00312. www.nature.com/scientificreports
Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated Cellular Telephones Affects Neurodevelopment and Behavior in Mice
Lunes 2 de abril de 2012 · 1673 lecturas
Fetal Radiofrequency Radiation Exposure From 800-1900 Mhz-Rated
Cellular Telephones Affects Neurodevelopment and Behavior in
Mice
Tamir S. Aldad1,2, Geliang Gan2, Xiao-Bing Gao2,3 & Hugh S. Taylor1,2,4
1Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, 2Department of
Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, 3Section of
Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, 4Environment and Human Health, New
Haven, CT.
Neurobehavioral disorders are increasingly prevalent in children, however their etiology is not well
understood. An association between prenatal cellular telephone use and hyperactivity in children has been
postulated, yet the direct effects of radiofrequency radiation exposure on neurodevelopment remain
unknown. Here we used a mouse model to demonstrate that in-utero radiofrequency exposure from cellular
telephones does affect adult behavior. Mice exposed in-utero were hyperactive and had impaired memory as
determined using the object recognition, light/dark box and step-down assays. Whole cell patch clamp
recordings of miniature excitatory postsynaptic currents (mEPSCs) revealed that these behavioral changes
were due to altered neuronal developmental programming. Exposed mice had dose-responsive impaired
glutamatergic synaptic transmission onto layer V pyramidal neurons of the prefrontal cortex. We present
the first experimental evidence of neuropathology due to in-utero cellular telephone radiation. Further
experiments are needed in humans or non-human primates to determine the risk of exposure during
pregnancy.
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