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Cellular and Molecular Neurobiology, Volume 29, Numbers 6-7 / septiembre de 2009, 981-990

Immunohistochemical Study of Postnatal Neurogenesis After Whole-body Exposure to Electromagnetic Fields: Evaluation of Age- and Dose-Related Changes in Rats

Domingo 11 de octubre de 2009 · 989 lecturas

Immunohistochemical Study of Postnatal Neurogenesis After Whole-body Exposure to Electromagnetic Fields: Evaluation of Age- and Dose-Related Changes in Rats

Judita Orendáová1 , Eniko Raeková1, Martin Orendá2, Marcela Martoníková1, Kamila Saganová1, Kamila Lievajová1, Henrieta Abdiová4, Ján Labun3 and Ján Gálik1

(1) Institute of Neurobiology, Center of Excellence, Slovak Academy of Sciences, oltésovej 4, Koice, 040 01, Slovak Republic
(2) Faculty of Electrical Engineering and Informatics, Department of Theoretical Electrotechnics and Electrical Measurement, Technical University of Koice, Letná 9, Koice, 042 00, Slovak Republic
(3) Faculty of Aeronautics, Department of Avionics, Technical University of Koice, Rampová 7, Koice, 040 01, Slovak Republic
(4) Stredná zdravotnícka kola, Moyzesova 17, Koice, 040 01, Slovak Republic

Received: 12 November 2008 Accepted: 27 February 2009 Published online: 21 March 2009

Abstract It is well established that strong electromagnetic fields (EMFs) can give rise to acute health effects, such as burns, which can be effectively prevented by respecting exposure guidelines and regulations. Current concerns are instead directed toward the possibility that long-term exposure to weak EMF might have detrimental health effects due to some biological mechanism, to date unknown. (1) The possible risk due to pulsed EMF at frequency 2.45 GHz and mean power density 2.8 mW/cm2 on rat postnatal neurogenesis was studied in relation to the animal’s age, duration of the exposure dose, and post-irradiation survival. (2) Proliferating cells marker, BrdU, was used to map age- and dose-related immunohistochemical changes within the rostral migratory stream (RMS) after whole-body exposure of newborn (P7) and senescent (24 months) rats. (3) Two dose-related exposure patterns were performed to clarify the cumulative effect of EMF: short-term exposure dose, 2 days irradiation (4 h/day), versus long-term exposure dose, 3 days irradiation (8 h/day), both followed by acute (24 h) and chronic (1-4 weeks) post-irradiation survival. (4) We found that the EMF induces significant age- and dose-dependent changes in proliferating cell numbers within the RMS. Our results indicate that the concerns about the possible risk of EMF generated in connection with production, transmission, distribution, and the use of electrical equipment and communication sets are justified at least with regard to early postnatal neurogenesis.
Keywords Cumulative effect - Non-ionizing radiation - Rostral migratory stream - Quantitative analysis - BrdU immunohistochemistry - Newborn - Senescent

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